Incorporating cellular sorting structure for better prediction of protein subcellular locations
نویسندگان
چکیده
Department of Computer Science and Engineering, Shanghai Jiao Tong University, No. 800, 5 Dongchuan Road, Shanghai, China; MOE-Microsoft Laboratory for Intelligent Computing and Intelligent Systems of Shanghai Jiao Tong University, No. 800, Dongchuan Road, Shanghai, China; Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
منابع مشابه
MultiLoc2 and SherLoc2: improved prediction of subcellular protein localization
The function of a protein is highly correlated with its subcellular localization. However, determining the subcellular localization of a protein experimentally can be difficult and time-consuming. Computational methods for the prediction of subcellular locations of proteins from the sequence alone are an attractive alternative. MultiLoc2 [1] and SherLoc2 [3] both significantly extend and improv...
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MOTIVATION Subcellular localization is a key functional characteristic of proteins. A fully automatic and reliable prediction system for protein subcellular localization is needed, especially for the analysis of large-scale genome sequences. RESULTS In this paper, Support Vector Machine has been introduced to predict the subcellular localization of proteins from their amino acid compositions....
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MOTIVATION Protein subcellular localization is pivotal in understanding a protein's function. Computational prediction of subcellular localization has become a viable alternative to experimental approaches. While current machine learning-based methods yield good prediction accuracy, most of them suffer from two key problems: lack of interpretability and dealing with multiple locations. RESULT...
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MOTIVATION Functional annotation of unknown proteins is a major goal in proteomics. A key annotation is the prediction of a protein's subcellular localization. Numerous prediction techniques have been developed, typically focusing on a single underlying biological aspect or predicting a subset of all possible localizations. An important step is taken towards emulating the protein sorting proces...
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ورودعنوان ژورنال:
- J. Exp. Theor. Artif. Intell.
دوره 23 شماره
صفحات -
تاریخ انتشار 2011